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IVF with donor biomaterial

The IVF process involves an ovocyte retrieval from a woman, fertilization using husband's sperm, embryos culture and transfer to the uterus. This is the standard sequence of in vitro fertilization. However, what to do if it is impossible to get the germ cells from the woman and her husband? The donor biomaterial is used in such situations.

When donor germ cells are used?

Depending on the situation, it is possible to use the biomaterial from a female or a male donor, or both of them. The ovocytes are retrieved from women, and sperm cells from men. Each case has its own indications. Usually these are different types of infertility when the germ cells quality suffers, or the germ cells are completely absent. Among other indications are the following:

  • The presence of genetic diseases in one or both spouses.
  • Surgeries performed on the reproductive organs.
  • Specific treatment (chemotherapy, X-ray therapy).
  • Immunological incompatibility of partners.
  • Previous unsuccessful IVF attempts that used partner’s germ cells.

It is worth to mention that donor biomaterial can be used either by married couples or by single women who want to have a baby.

Features of donor biomaterial use

Usually, donor material is stored frozen in special conditions. All personal data of the donor are classified and protected. Potential parents have only restricted information such as eye colors, height, weight, nationality and some other parameters. At the same time, all donors before the collection of material undergo a thorough examination; the purpose of examination is to exclude concomitant diseases and confirm the quality of germ cells.

Special freezing methods prevent damage of cells and DNA. After defrosting, the specialist examines the material under a microscope again and selects the best samples that will be used in the fertilization process. There is no difference between IVF with donor biomaterial and IVF with germ cells of spouses, with the exception of the retrieval phase. In both cases, the fertilization process takes place "in vitro", and then the embryos are cultured for several days; after microscopic examination, they are transferred into the uterine. There is a version of the program that uses ready-made donor embryos. In this case, the transfer stage begins immediately after the diagnostic and preparation procedures.

The doctor places several embryos in the uterus in order to increase the chances of pregnancy. Usually only one embryo survives, but the chance of a multiple pregnancy remains, and it must be taken into the account. The plan for IVF with donor material is always individual for each pair. There are several programs that involve the use of donor germ cells:

  • IVF with donor sperm
  • IVF with donor ovocytes
  • IVF with donor ovocytes and donor sperm
  • Surrogate maternity programs using donor material

Therefore, there is always a chance to become parents, even in the most difficult situations. All types of in vitro fertilization programs are conducted in our clinic, including using donor biomaterial and surrogate maternity.