IVF with donor ovocytes
The procedure of artificial insemination helps become parents to many couples. Even in cases with poor prognosis, it is possible to achieve a successful result using different techniques of assisted reproductive technologies. Such advanced methods include IVF with donor ovocytes. It allows the artificial insemination in the presence of the female factor.
How the selection is performed and in what cases the donor ovocytes are used — we will reveal all these and other questions in this article.
Indications for IVF with donor ovocytes
The main reasons for donor ovocytes usage are the lack or the low quality of the own ovocytes, which happens in the following case:
- Early menopause, low ovarian reserve.
- Lack of response from the ovaries to stimulation.
- Congenital diseases with underdevelopment of the sexual glands. This, for example, the Turner syndrome.
- Chemotherapy and radiation therapy.
- Absence of ovaries due to surgical removal or trauma, congenital anomaly.
- High risk of genetic diseases linked with the X chromosome.
- Previous unsuccessful IVF attempts. They can be associated with low quality of own ovocytes, poor response to stimulation.
- Immune incompatibility targeting an embryo or placenta.
“Fresh” and cryopreserved ovocytes
Cryopreserved or “fresh” donor ovocyte can be used for fertilization. In the first case, the biomaterial is prepared in advance and stored in a cryobank. Ovocytes are processed, the donor — examined. The couple chooses biomaterial according to the questionnaire suitable for the parameters (color of eyes, skin, hair, height and weight, blood group and Rh factor, character, education), then it is defrosted and fertilized at the right moment.
If “fresh” ovocytes are used, the couple usually knows the donor. This is either a close person or a relative of the spouse. At the IVF Center Vitalis, we work either with frozen and “fresh” ovocytes.
All donors are screened, whether anonymous or not. Requirements:
- Blood tests — Complete blood cells, biochemistry, blood type and rhesus, infection diseases.
- Chest X-ray.
- Tests for hereditary diseases.
- Gynecologist examination.
The other donor requirements: the absence of mental disorders, excellent somatic health, age from 18 to 34 years, the absence of hereditary diseases in the family, the absence of harmful factors.
How is IVF performed with donor ovocytes?
The steps are the same as with conventional IVF, but the main work is done with the donor. First of all, an examination of the donor and the future mother is performed. If everything is fine, proceed to the menstrual cycle synchronization of both women using the hormone therapy. Then perform a puncture and retrieve the ovocytes. The next stage is fertilization and embryo culture. At the embryos “age” of 3-5 days we perform the transfer into the uterus of the future mother.
If material from a cryobank is used, the procedure is simplified: there is no need to synchronize the menstrual cycle, hormonal medications usage. All manipulations are adapted to the natural women cycle. At the time of ovulation, donor ovocytes are thawed and fertilized. Further steps you already know.
It is necessary to pay attention to the following points.
- Endometrial thickness. If it is immature, the embryo will not be able to attach and a miscarriage may occur. If necessary, the doctor administer hormones to prepare the endometrium for implantation.
- At the time of transfer woman should be healthy, without any acute diseases and exacerbations of chronic pathology.
- Before and after fertilization, it is necessary to stop the harmful habits, drug use, if they are not vital. Hot baths, saunas, stresses and physical activity are contraindicated.
Husband examination with IVF
If it is not planned to use the donor sperm, the future father is also being examined by the urologist-andrologist with the following tests:
- Sperm analysis.
- Urethral smear to reveal genital infections.
- Fluorography and ECG.
- Analysis of antisperm antibodies.
If necessary, he undergoes the hormone profile tests and examinations of other specialists.
How to behave yourself after the embryo transfer?
Pregnancy is a period in a woman’s life when she must be especially careful. Pregnancy as a result of IVF is a reason to take more care of yourself and the child. What rules should follow a woman?
- Sexual rest during the first two weeks after embryo transfer, and longer if the doctor deems it necessary. After 2 weeks, we determine the level of hCG — it must be high, after some time we perform an ultrasound scan. According to the examination results, it will be clear whether the pregnancy has occurred or not, and whether there are any threats.
- Physical activity — at first we recommend the bed rest. Excessive physical activity, sports, especially lifting weight is contraindicated.
- Hot baths should also be postponed for some time.
- You should not take medications without consulting a doctor, even vitamins.
Diet should be various, food intake — frequent. Both overeating and starvation are unacceptable.